ABSTRACT
Skin lesions in affected buffaloes were either closed [166 cases] or open [81 cases]. Forms of closed lesions [non-suppurative] included regional oedema [96], subcutaneous nodules [60] and granulating overgrowth [10]. According to duration of the disease open lesions [suppurative] were acute [47], sub-acute [19] or chronic [15]. Animals treated with combination of systemic anti-inflammatory, anthelmentic drugs and antibiotics showed the highest response. It was concluded that the use of broad spectrum anthelmentic [like ivermectine or levamisole] in combination with antibiotic and anti-inflammatory drugs can increase the response to treatment by improving unspecific immunity; the effect of the exotoxins of C. pseudotuberculosis indicates that further researches for production of toxoid are essential for controlling the disease